I had, a little while ago, a pretty decent idea inspired by some recent research papers on COVID-19 (specifically ones about the vaccine blood clot issue, and interactions with the microbiome). I liked the idea I had, and shared it with a few friends and acquaintances first, then, feeling like it deserved to be critiqued by actual hospital researchers, I took a gamble and sent an email to a lab at SickKids in Toronto. With luck it will get a positive response. I chose SickKids because when I was a baby they saved my life.
I have no idea if this idea is something other people have already thought of, or if it’s novel in whole or in part, but I’m hopeful that it at least spurs some creative thought, if nothing else. I can’t possibly research it alone- I would need to know a whole lot more about the human immune system, and my background is soil microbiology, plus I’m currently unemployed- but if this idea helps, I’m all for sharing. I’m reminded of the physicist who got magnets up his nose trying to invent a COVID-19 face shield- I hope this effort to assist research relevant to treating COVID-19 will be more helpful than that!
If I can find someone to critique it (basically, it’s a complex explanation for why certain people get differing symptoms from infection or the vaccines), and it passes muster, I’ll see about publishing it. I’ve learned that no one wants just a hypothesis, not even bioRxiv, so with any luck I can work with someone to test this so it can be shared. I know I could just put it on this blog but I would like to see it formally published if I can.
I also had some ideas for clinical trial data analysis- and how to analyze sets where there may be outliers, which is probably all of them, without just omitting the outliers, which could provide important data. I wrote a quick description of the idea but it’s pretty rough- a bioinfomatician friend looked it over and didn’t quite understand the key part. I need to word it a little more clearly. So I have to revise that, and then see if I can interest anyone in trying it out. It would probably be useful in studies of COVID-19 vaccine responses, given the rarity of responses like blood clots.
I’ve had more complicated ideas for how to contrast things like complex immune system responses over time, but that’s another story entirely. I am fairly sure when I make statements like this I’m not believed, but if I gave up every time someone told me I was unable to do a thing I’d be living in a basket.